Curcumin merupakan senyawa hantu, dimana dia dalam uji in vivo memiliki efek, namun setelah di cek ketersediaannya didalam darah tidak mampu terdeteksi. Ada dugaan bahwa yang aktif dan berefek adalah metabolit curcumin. Adapun metabolit curcumin tersebut antara lain sebagai berikut :

image

GVT, PGV, dan HGV merupakan senyawa turunan curcumin. Sama halnya dengan curcumin, Ketiga senyawa tersebut memiliki sifat yagn sama, yakni hantu. Ritmalleni 2010 telah mensintesis senyawa yang diduga metabolit curcumin, yakni THPGV dan THGVT. Sedangkan senyawa metabolit lainnya belum, seperti turunan asam ferulic acid dan dihydroferulic acid. Nah…mensintesis turunan asam ferulic acid dan turunan dihydroferulic acidnya dari senyawa GVT, PGV, dan HGV???

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